文件名称：Circulating microRNAs
文件大小：3.73MB
文件格式：PDF
更新时间：2018-02-26 04:34:28
miRNA
MicroRNAs are fine tuners of diverse biological responses and are expressed in various cell ty of the liver. Here we hypothesized that circulating microRNAs (miRNAs) may serve as biomarkers of liver damage and inflammation. We studied miRNA-122 that is abundant in hepatocytes and miR-155, -146a and -125b that regulate inflammation in immune cells in mou models of alcoholic liver disease (ALD), drug (acetaminophen; APAP)-induced liver injury (DILI), and Toll-like receptor (TLR) 9+4 ligands-induced inflammatory cell-mediated liver