文件名称：BRCA1 及其相互作用蛋白的作用
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更新时间：2024-07-19 12:46:17
学术 论文
Roles of BRCA1 and its interacting proteins Roles of BRCA1 and its interacting proteins Chu-Xia Deng� and Steven G. Brodie Summary Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppres- sors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators (cyclins and