文件名称：The Ran-GTPase and cell-cycle control
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更新时间：2024-07-19 09:48:15
学术 论文
Problems and paradigms The Ran-GTPase and cell-cycle control Jonathan D. Moore Summary HowdoesRCC1work?RCC1wasfoundtocopurifywith RCC1, the chromatin-bound guanine-nucleotide ex- Ran, a 25 kDa protein previously identified in a search for changefactor(GEF)forthesmallnuclearGTPase,Ran, Ras-related proteins.(5,6) RCC1 proved to be a guanine- is required for coordinating the onset of mitosis with S-phasecompletioninmammaliancells.Otherdefectsin nucleotideexchangefactor(GEF)fortheRan-GTPase;(7)by th