文件名称：The structure and function of HFE
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更新时间：2024-07-19 13:42:22
学术 论文
The structure and function of HFE The structure and function of HFE Hal Drakesmith* and Alain Townsend Summary The iron overload disease hereditary haemochromato- sis (HH) occurs in about 1 in 300 Caucasians; the protein mutated in this disorder is termed HFE.(1) HFE is homologous to major histocompatibility complex (MHC) class I proteins, but unlike MHC class I mole- cules, HFE does not present peptides to T cells.(2) The transferrin receptor (TfR) is a ligand for HFE, and the crystal struct