文件名称：ANGIOTENSIN-I CONVERTING ENZYME INHIBITORY ACTIVITIES
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更新时间：2021-04-06 08:50:51
血管紧张素 转化酶
Antioxidant and antihypertensive potential of ethyl acetate-methanol (EtOAc-MeOH) extract of cephalopods, Amphioctopus marginatus, Uroteuthis duvaucelii, Sepia pharaonis, Sepiella inermis and Cistopus indicus were evaluated using different in vitro systems. EtOAc-MeOH fractions of S. inermis, A. marinates and C. indicus showed greater ferrous ion chelating ability (IC90 5.01–5.8 mg/mL), and were effective in neutralizing the ABTS (IC90 3.5–4.01 mg/mL), and DPPH radicals (IC90 4.69–5.8 mg/ mL). The utilities of deconvolated 1H and 13C-NMR spectroscopy for analyzing the signature peaks and abundance of bioactive functional groups in the extracts of cephalopods were illustrated. The EtOAc-MeOH extract derived from S. inermis showed greater angiotensin-converting enzyme-I (ACE-I) inhibitory activity (IC90 0.45 mg/mL) than other cephalopods (IC90>0.50 mg/mL). A significant colinearity was found between the electronegative groups present in the downfield position of NMR spectra vis-a-vis antioxidative and ACE-inhibitory activities of EtOAc-MeOH extracts from C. indicus and S. inermis.