首先到https://info.flexerasoftware.com/IS-EVAL-InstallShield-Limited-Edition-Visual-Studio填写信息：
完成之后跳转到授权页面：
下载安装完毕后，打开vs2015：
新建工程后：
生成：
解决.NetFramework4.6以上版本问题：
以4.6.1为例：
首先新建文件txt文件编辑：
<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<SetupPrereq>
<conditions>
<condition Type="2" Comparison="2" Path="HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\NET Framework Setup\NDP\v4\Full" FileName="Version" ReturnValue="4.6.01055"/>
</conditions>
<operatingsystemconditions>
<operatingsystemcondition MajorVersion="6" MinorVersion="1" PlatformId="2" CSDVersion="" Bits="4" ServicePackMajorMin="1"/>
<operatingsystemcondition MajorVersion="6" MinorVersion="2" PlatformId="2" CSDVersion="" Bits="4"/>
<operatingsystemcondition MajorVersion="10" MinorVersion="0" PlatformId="2" CSDVersion="" Bits="4"/>
</operatingsystemconditions>
<files>
<file LocalFile=".\Microsoft.net\4.6\Full\NDP461-KB3102436-x86-x64-AllOS-ENU.exe" URL="https://download.microsoft.com/download/E/4/1/E4173890-A24A-4936-9FC9-AF930FE3FA40/NDP461-KB3102436-x86-x64-AllOS-ENU.exe" CheckSum="864056903748706E251FEC9F5D887EF9" FileSize="0,67681000"/>
</files>
<execute file="NDP461-KB3102436-x86-x64-AllOS-ENU.exe" cmdline="/q /norestart" cmdlinesilent="/q /norestart" returncodetoreboot="1641,3010"/>
<properties Id="{C267632F-EAD4-478E-B578-E72D9C6D87F2}" Description="This prerequisite installs the .NET Framework 4.6.1 full standalone package."/>
<behavior Reboot="32"/>
</SetupPrereq>
<properties Id="{C267632F-EAD4-478E-B578-E72D9C6D87F2}" Description="This prerequisite installs the .NET Framework 4.6.1 full standalone package."/>
Id为如下字符，安装时若没有.netframework4.6.1会自动选择安装
重命名为：Microsoft .NET Framework 4.6.1 Full.prq 移动到C:\Program Files (x86)\InstallShield\2015LE\SetupPrerequisites文件夹下
打包。
参考：https://community.flexerasoftware.com/showthread.php?220164-prq-for-Microsoft-NET-Framework-4-6-1-Full